Marine Ircinia and Haliclona sponges (Porifera) associated bacteria were isolated and screened for antibacterial and antifungal activities against selected clinical isolates of bacteria, multidrug resistant strains and fungal strains. These isolated extracts were also screened for antitubercular activities by LJ media method. Methanolic and ethyl acetate extracts of three marine organisms demonstrated activity against one or more of microbes tested. NIO MAM 11.3, NIO MAM 4.2 and NIOMAM 4.1 strains were most active and exhibited a broad-spectrum antimicrobial activity against each of the microbe tested. Two of them were mass cultured with Zobells Marine Broth media .Ircinia sponge associated bacteria specifically showed activity against Vibrio cholera, MDR Acinetobacte and, Aspergillus fumigatus whereas the Haliclona sponge associated bacterial extract against Staph.aureus, S.Typhi, Shigella, Klebsiella species and Vibrio cholerae exhibited considerable antibacterial activity, respectively.
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